Islets of Langerhans during Type I Diabetes

Destruction of Tissue, Cells and Organelles in Type 1 Diabetic Rats Presented at Macromolecular Resolution
Raimond B. G. Ravelli1, Ruby D. Kalicharan2,M. Cristina Avramut1, Klaas A. Sjollema2, Joachim W. Pronk1, Freark Dijk2, Abraham J. Koster1, Jeroen T. J. Visser2, Frank G. A. Faas1 and Ben N. G.Giepmans2
Scientific Reports (2013) 3, 1804;
1Dept.MolecularCell Biology, Leiden University Medical Center, P. O. Box 9600, 2300 RC, Leiden, The Netherlands,
2Dept. of Cell Biology, University Medical Center Groningen, University of Groningen, P. O. Box 196, 9700 AD, Groningen, The Netherlands.

Click below for an introduction to ultrastructure
23 mM blood glucose (BG); Islet V
23mM
I - 6.6 mM BG
DR
II - 7.2 mM BG
7p2mM
III - 9.9 mM BG
9p9mM
IV - 12 mM BG
12p4mM
V - 23 mM BG
23mM
VI - >30 mM BG
gt30mM